Temozolomide Basic information
Product Name: Temozolomide
Synonyms: 4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide;TEMOZOLOMIDE;1-d)(1,2,3,5)tetrazine-8-carboxamide,3,4-dihydro-3-methyl-4-oxo-imidazo(;3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide;3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide;8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3h)-one;ccrg81045;m&b39831
CAS: 85622-93-1
MF: C6H6N6O2
MW: 194.15
EINECS:
Product Categories: Active Pharmaceutical Ingredients;Antineoplastic;Intermediates & Fine Chemicals;Pharmaceuticals;Antitumour;Bases & Related Reagents;Heterocycles;Nucleotides;Displays antitumor activity.;API;TEMODAR
Temozolomide Chemical Properties
mp 212°C dec.
storage temp. 2-8°C
CAS DataBase Reference 85622-93-1(CAS DataBase Reference)
Temozolomide Usage And Synthesis
Chemical Properties Off-White to Light-Pink Crystalline Solid
Usage Imidazotetrazine alkylating agent. An antineoplastic.
Usage inhibits cancer cells similar to paclitaxel effective against paclitaxel-resistant tumours
Biological Activity DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC 50 = 5.0 μ M for cytotoxicity against mouse TLX5 lymphoma cells).